Silencing of RRM1 likewise inhibited the accumulation of lipid peroxides in response to erastin2 treatment, as determined by confocal imaging of the lipid peroxidation probe C11- BODIPY 581 591, whose oxidation is highly correlated with the onset of ferroptosis Dixon et al, 2012; Magtanong et al, 2019; Conlon et al, 2021 Fig 5C. doxycycline long term side effects
