For each experiment, mice were randomly distributed into equal groups 3 4 mice per group that were untreated, or treated by intratumoral injections every 5 days 4 cycles with 1 mg kg or 4 mg kg doxorubicin, 10 mg kg paclitaxel, 20 mg kg carboplatin, 200 Ојg mL metformin diluted in drinking water and present throughout the experiment starting at day 10, or combinations that included metformin summit health gynecology increased blood pressure, bone pain, weakened bones, and